While Napoleon Dynamite may have made these guys famous, they actually do exist. I have read they they grow to enormous sizes (ie much larger then normal lions/tigers) because a certain growth-promoting gene is not repressed.
National Geographic News Photo Gallery: “Dynamite” Pictures of Ligers
Check the wikipedia entry for more info … or if you don’t know what a Liger is.
Update: You can also check out these pictures (via digg) as well.
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